by New research reveals that a protein present in the saliva of mosquitoes can hinder the host’s immune response, providing an explanation for the insect’s ability to efficiently transmit diseases like malaria and dengue fever.
Scientists at the University of California, San Diego (UCSD) have identified a protein called Agammapterin, which is secreted by the Anopheles mosquito during a bite. Agammapterin was found to inhibit the host’s immune system, allowing the parasites responsible for malaria to enter and multiply in the liver.
According to the study published in the journal Cell Reports, Agammapterin blocks the production of a specific immune molecule called interferon gamma (IFN-γ), which plays a crucial role in activating the host’s immune cells to fight infections. By suppressing the immune response, the mosquito’s saliva enables the parasites to evade detection and establish an infection.
The researchers also discovered that Agammapterin works in a similar way to inhibit the immune response against dengue virus. This finding could potentially lead to the development of new strategies to prevent or treat mosquito-borne diseases.
The team plans to further investigate the role of Agammapterin in the transmission of other mosquito-borne diseases, such as Zika virus and West Nile virus. Understanding the molecular mechanisms behind the mosquito’s immune evasion tactics could pave the way for the creation of novel interventions to protect humans from these debilitating diseases.
In summary, a protein named Agammapterin, present in the saliva of Anopheles mosquitoes, has been identified as a key player in inhibiting the host’s immune response against malaria and dengue fever. By blocking the production of interferon gamma, Agammapterin enables the parasites to evade detection and establish an infection, highlighting the importance of this discovery in the quest for new prevention and treatment strategies for mosquito-borne diseases.
About Author - Priya Pandey
Priya Pandey is a dynamic and passionate editor with over three years of expertise in content editing and proofreading. Holding a bachelor's degree in biotechnology, Priya has a knack for making the content engaging. Her diverse portfolio includes editing documents across different industries, including food and beverages, information and technology, healthcare, chemical and materials, etc. Priya's meticulous attention to detail and commitment to excellence make her an invaluable asset in the world of content creation and refinement. LinkedIn Profile
